Kunal Shah - Bryan Johnson

1) Bryan Johnson shares his journey towards finding ways to create meaningful change for humanity and how he used payments as a path to generate money to fund his endeavors. He talks about his venture fund, OS Fund, which focuses on investing in companies that engineer the physical world, such as Ginkgo Bioworks, a leader in synthetic biology. Johnson aimed to build a layer of technology that allows people to engineer the physical world at the atom and molecule level using synthetic biology, computational therapeutics, among others. He invested $100 million into the fund to support these endeavors and was able to work with scientists and entrepreneurs to achieve his goals.

2) Bryan discusses his work at Kernel, a company that aims to engineer the world around us through the quantification of the brain. Johnson explains how the lack of measurement around the brain has limited our ability to engineer the world around it, and how Kernel's technology can help quantify the brain in a quantitative framework. The development of this technology, which is currently being commercialized for depression and cognitive decline, would revolutionize the way we think about brain health, providing a way to track and monitor the most important organ in our body in the same way we track our sleep and exercise with wrist trackers.

3) Bryan discusses the need for humans to reverse the equation of sacrificing themselves for technology and instead use technology for the betterment of humans. He explains that he came to this realization after experiencing chronic depression and self-destructive behavior, which he couldn't control. He then had an "Abracadabra" moment when he realized that he was not a single identity but many versions of himself, and he had power over them. He also discussed how his experience as a pilot inspired him to create an autopilot for humans.

4) Bryan discusses his struggle with self-discipline and how he rebuilt his reality by remapping pleasure to discomfort and seeking slight discomfort. He implemented a system in his life where all his decisions are made for him as he knows he cannot trust himself to make the right choices. He believes that algorithms can take better care of him than he can himself based on science and data, and his company Blueprint aims to demonstrate this fact. Johnson argues that this is a demonstrated inevitability, and it is the most exciting thing as it allows humans to walk into the next phase of evolutionary existence.

5) Bryan discusses the criticism he has received for his Blueprint program, which he describes as a commentary on society's approach to addiction. Johnson believes that society has made it easy and normal to engage in self-destructive behaviors, such as consuming unhealthy food and digital media, leading to an overall feeling of unhappiness and helplessness. However, he also notes that the Blueprint principles, which include stopping behavior such as excessive eating, drinking, and smoking, prioritizing sleep, and eating nutritious foods, are accessible to everyone, regardless of wealth. Johnson acknowledges that the Blueprint program is expensive but adds that there are low-cost versions available, and the basic principles of the program are applicable to everyone and do not require any monetary investment.

6) Bryan discusses how he achieved a consistently high score on his sleep quality using his elaborate routine that he built his life around. Johnson eats his meals within a six-hour window from 6 am to noon every day and fasts for 18 hours, which he found to be the best predictor of his sleep quality. He also has an hour of wind-down time with his family before sleeping, in which they stretch, talk, and forget about the day's events. Johnson blacked out his room and ensures that he sleeps independently to avoid disturbances.

7) Bryan discusses how improving the quality of our lives can solve the root of our problems, such as violence and addiction. He explains how Blueprint is a revolution and evolution of future Being Human, to align individual goals and achieve better mental and physical health. Later, the conversation shifts to the impact of addictive content on young people and the current state of their brains, to which Johnson offers a controversial idea that he solved his problem with being human by putting aside his most valuable tool, his mind, to empower his organs to decide how he lives.

8) Bryan speaks about his belief that humans may need to consider setting aside their minds as the architects of our existence and adopt a different approach. By using measurable data to understand what our organs need to function optimally, Johnson created a clinical-grade protocol that has vastly improved his well-being. He believes that if we want to thrive as a species and create a sustainable future, we need to reconsider our relationship with our minds and embrace technological advancements such as AI that can radically extend human life. He encourages people to be in the game for as long as possible and not miss out on what's coming next.

9) Bryan shares his top three predictions for the future of human life and health in this decade. Firstly, he believes that humans will accept that an algorithm does a better job of taking care of their health than they can themselves. Secondly, Johnson thinks that once humans accept that decay and decline may not be inevitable, it will dramatically change how we think about the world and each other. Humans may become more compassionate as a species, becoming less prone to war, violence, and being at each other's throat. Finally, Johnson believes that we can continue to evolve as a species. As we become more compassionate, we may raise our aspirations on what we can achieve and create a new frontier of exploration in our conscious existence.

10) Bryan discusses how AI and its ability to introduce zeroth principle insight is changing the architecture of human existence. Bryan asserts that we are walking furiously into a zero principle future where the speed of computational thought is changing the pace of our existence. However, he emphasizes that our number one characteristic is how fast we can adapt and become adaptable as a species, not our intelligence. Rather than being fearful, we should embrace the zero principle and work towards a future which could be more majestic than anything we've ever imagined.